Mesothelioma Cancer

by Peter Nisbet

There are various types of mesothelioma but asbestos lung mesothelioma is an asbestos-induced cancer of the mesothelium of the lung, more familiarly known as the pleura, which is the external lining of the lung.

Many of the major organs of the body have a mesothelium, that of the heart being called the pericardium and of the heart the peritoneum. However, it is with the pleura that we are concerned here, and the symptoms of asbestos lung mesothelioma are what you would expect: coughing, discomfort in the chest cavity and eventual pain.

Before we come to possible treatments and palliative care, let’s have a look at what causes it and why we are still seeing new cases today after asbestos was banned for construction use in the 1970s.

Asbestos comes in several forms, the most dangerous thought to be crocidolite, commonly known as blue asbestos. This form of asbestos is in a highly fibrous form, and it is the inhalation and ingestion of these fibers that cause the problem. They tend to remain in the body for a considerable period of time and it can take up to 40 ��” 45 years before the symptoms of mesothelioma begin to appear, though some people contract it in their 30s.

To complicate the situation, it is not only asbestos that causes the symptoms, but any fibrous silicate, which it is why some compensation cases are not as cut and dry as they could be. To add to this complication, smoking adds to the possibility of cancer and it is argued that many patients would not have contracted mesothelioma had they not smoked.

This is not only an argument made by solicitors in court, but has been established by statistics. It is pretty certain that smokers have a greater tendency of contracting asbestos lung mesothelioma than non-smokers, since attorneys for the employers have used this as a reason for having the otherwise high compensation significantly reduced.

There is a popular misconception that mesothelioma is caused by asbestos, but it is just a misconception. Lung cancer is mesothelioma, and in the USA 80% of mesothelioma cases are caused by smoking. That is an indisputable fact. In order to prove the intervention of asbestos in a case, therefore, not only would the patients have to prove that they had worked with asbestos, but also not to have smoked. Had they smoked, then the award could be greatly reduced.

The term “asbestos lung mesothelioma” is therefore a correct one because that form of the disease to which we are referring is caused by asbestos, and not smoking, is of the pleura of the lung and not of the pericardium or peritoneum, and is mesothelioma.

Its treatment is largely palliative, or intended to ease suffering, because the prognosis is fairly grim. Only about 20% of cases live to 5 years after diagnosis, with most surviving only one year, though much depends on how far the condition had developed by the time it was diagnosed. Chemotherapy and radiation treatment are used, but not successfully, and various degrees of surgery are also used. Removal of the affected lung, pericardium and half the diaphragm is the most major of these, and even that only extends life to a maximum of around five years from diagnosis.

There are new treatments being tested, but all treatment is expensive, and a good attorney is likely necessary to secure the compensation to pay for these. Ultimately hospice care will be required and again compensation money should be kept back for this. Ultimately, in spite of all the treatment given, it is palliative care that will make the last days of the patient bearable, as will the help and support of the family, and this is what compensation can fund.

About the Author
More information on this disease can be obtained from Pete’s webpage Asbestos Lung Mesothelioma where more detail is given of possible treatment.

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Malignant mesothelioma (cancer of the mesothelium) is a disease in which cells of the mesothelium become abnormal and divide without control or order. It is a rare form of cancer that most frequently arises from the cells lining the sacs of the chest (the pleura) or the abdomen (the peritoneum). Malignant mesothelioma is closely linked to exposure to asbestos - a natural fiber that was once used in manufacturing a wide variety of industrial and household products. Workers involved in asbestos mining, milling and manufacturing are at the greatest risk for developing malignant mesothelioma. Also at high risk are shipyard workers, workers in the heating and construction industries, and other tradespeople. Family members and others living with asbestos workers have an increased risk of developing malignant mesothelioma, and possibly other asbestos related diseases as well. Cases of malignant mesothelioma have even included people whose only exposure was breathing the air through ventilation systems.

Although reported incidence rates have increased in the past 20 years, malignant mesothelioma is still a relatively rare cancer. Between 1973 and 1984, there has been a threefold increase in the diagnosis of pleural mesothelioma in Caucasian males. From 1980 to the late 1990s, the death rate from malignant mesothelioma in the USA increased from 2,000 per year to 3,000, with men four times more likely to acquire it than women. The actual rates may be even higher however, since it is possible that many cases of malignant mesothelioma are misdiagnosed as adenocarcinoma of the lung, which is difficult to differentiate from mesothelioma.

The average age of diagnosis of malignant mesothelioma is 60. The average survival time varies from 4 to 18 months, and death is usually due to infection or respiratory failure from the progression of the mesothelioma.

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Mesothelioma cancer is the growth of malignant cells in mesothelium. This mesothelium lining covers the pleural, peritoneal and pericardial cavities. Pleura is a membrane covering the lungs and it is the most common location where mesothelioma cancer occurs also known as pleural mesothelioma. Peritoneum, the protective covering that lines the abdominal cavity may also develop malignant tumors and cause peritoneal mesothelioma.

Mesothelioma is one of the rarest cancers in the world that is caused only by exposure to asbestos. Its exposure can be direct, by inhalation of asbestos or indirect exposure in which the asbestos particles are inhaled from the clothing, hair, equipment or other articles that were previously exposed to asbestos.

Causes of Mesothelioma
Asbestos is a naturally occurring fibrous mineral that is mined in different parts of the world due to its wide utility in various industries. However, it is a deadly carcinogen too and a mojor cause of mesothelioma and asbestosis.

Asbestos fibers are known to cause cancer of the mesothelium. Asbestos is the fibrous form of several minerals and hydrous silicates of magnesium found under ground. There are 3 types of asbestos, the blue one, the while one and the brown one. Of all these 3 types, the blue one also called amphibole, long and thin in structure is more carcinogenic than white or chrysolite asbestos or the brown one known as amosite.

However, in some cases the brown asbestos has also been found to cause mesothelioma. And it is for this reason that people exposed to asbestos even for a short period are vulnerable to the disease.

Pleural Mesothelioma
Asbestos fibers are very fine and easily make their way to the lungs where they settle down in the parenchyma of the lung and penetrate the pleura that later develops malignant mesothelial plaques.

Pleura, which anchors lungs to the chest cavity, is itself a double-layered membrane. The inner layer called visceral pleura surrounds the lungs, while the outer one, known as parietal pleura, forms the lining of the pleural or chest cavity. The two pleural layers are filled with a fluid that helps them to slide over each other as we breathe. As the disease progresses, the delicate pleural membranes thicken and press the lungs. A fluid secreted by the malignant cells, pleural effusion, may also collect between visceral and parietal pleurae that causes problem in breathing and other complications.

Peritoneum Mesothelioma
The asbestos fibers may also cause cancer in the peritoneum, known as peritoneal mesothelioma. This leads to thickening of the membranes surrounding abdominal organs and collection of a fluid, ascites in the abdominal cavity making it swell.

Though it is yet not clear how peritoneal mesothelioma develops, it is believed that from lungs, the asbestos fibers are transported to abdomen and its organs by the lymphatic system or they may be deposited in the gut through saliva contaminated by the asbestos fibers.

Pericardial Mesothelioma
This is the rarest type of mesothelioma cancer that comprises of only 5% of all the mesothelioma cases. Like other types of mesothelioma cancer, pericardial mesothelioma is also caused by the inhalation of asbestos dust and fibers. The lining of the chest cavity which protects the heart is known as pericardium. It is provided with a natural fluid or mucous that provide continuous lubrication to the heart so that it can work properly and perform its functions.

As the asbestos particles settle further into the lining of the chest or pericardial, the cancer spreads in the body. It destroys the heart tissues and muscles that is very hazardous to life and proves fatal for the patient.

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What is mesothelioma?

Mesothelioma is cancer of the mesothelium. Like most cancers, mesothelioma involves the abnormal dividing of cells of a particular part of the body — in this case, the mesothelium. Mesothelioma is so deadly because it remains dormant for many years and then begins to rapidly expand. The cancer then begins to invade and damage nearby tissue, including the vital organs.

What is the mesothelium?

Many of the internal organs of the body are protected by a membrane called the mesothelium. This membrane actually consists of two layers of cells. The inner layer surrounds the organs, and the second is a sac surrounding the inner layer. When organs within this membrane must move, expand or contract — such as the heart, lungs, bladder, and so on, they are able to do so because the mesothelium produces a lubricating fluid between the two layers.

Mesothelioma most often begins in the pleura or peritoneum. The pleura surrounds the lungs and covers the chest cavity. The peritoneum covers most of the organs in the abdominal cavity. Other mesothelium tissue is also vulnerable to mesothelioma. These include the pericardium that surrounds and protects the heart; the tunica vaginalis testic which surrounds the internal male reproductive organs; and the tunica serosa uteri which is the membrane covering the internal reproductive organs in women.

Who is at greatest risk to develop mesothelioma?

Mesothelioma has a very specific cause - exposure to asbestos. During the first half of the previous century, right up until the mid 1970s asbestos was an important material used to insulate buildings, machines, heavy equipment, and a broad range of commercial applications. Because it was plentiful and inexpensive to mine, asbestos was used in many building products such as home insulation, floor, ceiling and roof tiles. It was also used in commonly found commercial products such as brake linings and pipe insulation.

This meant that millions of people were coming in contact with asbestos on a daily basis. And since the effects of exposure to asbestos fibre often do not become apparent for 30 or 40 years after prolonged exposure, companies and health officials were slow to recognize the dangers of asbestos. As a result, shipyard workers, men and women working in asbestos mines and mills, workers producing asbestos products, workers in the heating and construction industries, and virtually all other tradespeople were exposed to asbestos fibres for extended periods of time.

Today it is understood that anyone working with or near asbestos has an increased risk of developing mesothelioma, so there are strictly controlled limits of exposure in the work place. But since the dormancy period of mesothelioma can often be 30 or 40 years, there are millions of workers who are at risk because of their exposure in the decades before the safety controls were put in place.

What are the symptoms of mesothelioma?

Pleural mesothelioma - cancer of the pleura or lung lining - causes shortness of breath or chronic coughing. Other symptoms of pleural mesothelioma may include chest pain, chronic coughing, shortness of breath, fatigue, wheezing, hoarseness, weight loss, or blood in the phlegm from the lungs when coughing.

Peritoneal mesothelioma affects the lining around the stomach and intestines and is usually just as dangerous. Symptoms of peritoneal mesothelioma include pain or swelling in the abdomen, weight loss, bowel obstruction, anemia, and fever.

Many of the symptoms of mesothelioma can easily be mistaken for allergies or a common cold. Mesothelioma is often discovered when patients think they have one of these other common illnesses.

How Serious is Mesothelioma?

By the time most infected people become aware they have mesothelioma, it is no longer dormant and becomes extremely aggressive. In its active phase, mesothelioma can travel quickly, and is almost impossible to stop. There are treatments used to keep the patient comfortable, but there is currently no cure for mesothelioma. As many as 75% of those who develop the disease will lose their life within one year. The remainder may last for up to an additional six months.

This makes it extremely important to detect the disease before it enters its active phase.

How is mesothelioma diagnosed?

Mesothelioma is often not diagnosed until it reaches an advanced stage. This is because of its long dormancy period, and because once it becomes active the initial symptoms are similar to much more comman and less dangerous sicknesses such as colds or the flu. If a patient has a history of exposure to asbestos, then a complete physical examination is advised. This would normally include x-rays of the chest or abdomen and lung function tests. It might also include a CT (or CAT) scan or an MRI. Both of these tests give detailed pictures of areas inside the body.

If these tests indicate the probability of mesothelioma, then it is necessary to perform a biopsy to confirm the diagnosis. Doing a biopsy involves an oncology specialist taking a small sample of affected tissue and examining it under a microscope for signs of malignancy. Depending on the location of the affected tissue, doing a biopsy can be a relatively traightforward procedure. It normally involves the insertion of a small instrument into the suspect cavity. These surgical devices have both viewing and sample taking capabilities. So the oncologist or surgeon can look at the cavity from the inside, and then take tissue samples from different areas.

If mesothelioma is discovered, the initial tests are followed up with what is called “staging”. This involves more tests to determine how far the disease has spread.

How is mesothelioma treated?

Standard treatments include the normal options available to cancer patients: surgery, radiation therapy, and chemotherapy. Sometimes, these treatments are combined. If the mesothelioma is discovered at an early enough stage these treatments can sometimes be effective.

Among the treatments that are used in order to reduce the effects of the disease are oxygen, postural drainage and pain killers. Many alternative treatment methods are also being tested, including attempts to strengthen the body’s immune system. Gene therapy is also being tested in an attempt to attack the problem at the DNA level. Other treatments being tried and tested include homeopathy, herbs and acupuncture. Unfortunately none of these have been found to be very effective once the disease reaches its aggressive stage.

As with all cancers, early detection is the best defense against mesothelioma. Anyone who has been exposed to asbestos should be alert for symptoms and contact a doctor immediately. Detecting mesothelioma at the earliest stage possible greatly increases the chances of beating the disease.

About The Author

Rick Hendershot

For more information about Mesothelioma visit http://www.mesotheliomaadvisors.com ==> For more articles and reports about mesothelioma see http://www.mesotheliomaadvisors.com/reports.html ==> Rick Hendershot is a writer and online publisher. For publishing and promotion opportunities see http://www.linknet-blogs.com.

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