Mesothelioma Cancer

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by M Nelson

Research in alternative medicine and conventional therapies to treat Mesothelioma cancer continues to be on the forefront to try and find a cure for this disease. Until an alternative is discovered and shows promise, conventional drugs and therapies such as Alimta and other chemotherapy drugs, surgery to remove tumors, and radiation therapy will be used to slow the cancer growth.

In addition to conventional treatments, a number of therapies from alternative medicine may be able to reduce symptoms of mesothelioma. Called complementary and alternative medicine, or CAM, this diverse group of medical and health care options and practices aren’t considered to be a part of mainstream medical practice. However, that doesn’t mean that they’re ineffective. Some health care providers practice both CAM and conventional medicine, and combine the two with good results. This is referred to as integrative medicine. As much as thirty-six percent of America’s adult population are using some form of CAM. This rises to more than sixty percent if prayer and megavitamin therapy are included in the definition of alternative and complementary practices. Rates of alternative therapy use are highest among patients with serious illnesses such as mesothelioma cancer.

Some treatments offered by alternative medicine include acupuncture to relieve pain following surgery for tumor removal, ginger to treat the nausea and vomiting that chemotherapy causes, massage to treat pain from all kinds of cancers, and combining mistletoe extract with chemotherapy to treat tumors. Immunotherapy, also called biological therapy, is also becoming more common. In this therapy, substances called biological response modifiers are used to improve the immune system’s ability to recognize and destroy cancer cells, as well as to fight off other diseases.

Photodynamic therapy uses a drug that sensitizes tissues to light, then destroys cancerous cells by exposing them to a laser set to a specific frequency. Gene therapy is a new, but advancing field which treats potentially fatal diseases by modifying an individual’s genes therapeutically. Herbal medicines, traditional practices from countries such as China and Japan, and spiritual treatments are also used in CAM. Not all of these therapies have the ability to affect mesothelioma directly, and their effects will tend to vary by patient. However, they can be a big help in managing symptoms and side effects while using conventional treatments.

Those who are interested in using complementary or alternative medicine in their cancer treatment should ask their health care providers. It’s important to get the answers to a few questions when considering any therapy, whether alternative or conventional. Information such as the expected benefits of the therapy versus the risks, the potential side effects, and, in the case of alternative or complementary treatments, whether the therapy will interfere with treatments you’re already undergoing are helpful. If the therapy is part of a clinical trial, find out who the sponsor is. Many alternative therapies aren’t covered fully by health insurance. Some aren’t covered at all. It’s important to find out before beginning a CAM therapy whether or not your insurance will pay for it. A good place to start finding out about your options is the NCCAM website at http://nccam.nih.gov. From there, you’ll be able to get the information to decide what therapies, both conventional and alternative, are right for you.

About the Author
From personal research Maria Nelson provides an online research tool for cancer patients; with an emphasis on Mesothelioma cancer. Find resources to specialized cancer centers, doctors and a Mesothelioma attorneys directory for legal consideration.

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One rare form of cancer is called Mesothelioma, a malignant tumor in the mesothelial tissues of the lungs and the abdomen, arising from the inhalation of asbestos. Its rarity is one of the reasons why a lot of people are not aware of this kind of fatal disease. In fact, many people die of Mesothelioma undiagnosed. Although there is now a growing awareness of the hazards of asbestos to health, still many have not heard of Mesothelioma and thus, have not understood its nature, cause, signs and treatment. Even some physicians find it hard to detect Mesothelioma because its symptoms are akin to other diseases like lung cancer and pneumonia. Furthermore, it takes decades for a patient who was exposed to asbestos to develop Mesothelioma — fifty years, at most.

Being unaware of Mesothelioma poses higher risks since it deters diagnosis and treatment. A person undergoing treatment must know the different stages of the cancer or the extent of the disease. Chances of recovering from Mesothelioma and the kind of treatment depend on the stage of the illness. There are basically two staging systems used for Pleural Mesothelioma (lungs): TNM system and Brighan system. These staging systems are also used in other kinds of cancers; however, the first is commonly used. There is no established method in determining the stage of the Peritoneal Mesothelioma cancer (abdominal) so the TNM system is used.

There are three variables in the TNM system: tumor, lymph nodes and metastasis. In the earliest stage of Mesothelioma, stage I, the malignant Mesothelioma cells start to grow and multiply only one layer of the pleura. The pleura is the membrane that encloses the lungs and lines the wall of the chest cavity. However, there are some instances wherein the pericardium (membrane that covers the heart) and diaphragm cover are already affected. In this case, the cancer patient is still in stage I Mesothelioma.

In the second stage, the two layers of the pleura are already affected by Mesothelioma. Take note, however, that in this stage, only one side of the body is affected. Normally, the pleura produces only small amount of lubricating fluid that allows easy expanding and contracting of the lungs. The excess fluid is absorbed by the blood and the lymph vessels so there’s a balance between the amount of fluid produced and removed. During the second stage Mesothelioma, fluid starts to build up between the membrane of the lungs and the membrane of the chest wall, resulting to pleural effusion. The increase in the volume of fluid produced causes shortness of breath and chest pain. Other Mesothelioma cancer patients experience dry and persistent cough. Diagnosis of the pleural effusion is achieved through a chest x-ray.

Stage III Mesothelioma means that the malignant cells have already spread to the chest wall, esophagus and the lymph nodes on one part of the chest. The patient may suffer severe pain near the parts affected. When not treated immediately or when the Mesothelioma patient doesn’t respond well to medication, the cancer may advance to the fourth stage. The fourth stage Mesothelioma is formidable since at this stage the Mesothelioma cells have penetrated into the bloodstream and other organs in the body like the liver, the bones and the brain. The lymph nodes on the other side of the chest may also be affected by Mesothelioma in stage IV.

Brighan staging system, on the other hand, determines whether the Mesothelioma can be surgically removed or not and whether the lymph nodes are affected or not. In stage I Mesothelioma, the lymph nodes are not yet affected and the patient can still recover through surgery. In stage II, surgery can still be executed but some lymph nodes have already been infiltrated by the cancer cells. In stage III, the heart and chest wall are already affected; thus, surgery is no longer advisable. The lymph nodes in this stage, however, may or may not be affected. In the final stage, stage IV Mesothelioma, cancer cells have already gone to the bloodstream and other parts of the body like the heart, brain, bone and liver. In most cases, a patient who has reached stage IV Mesothelioma only has four to twenty-four months to live.

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Mesothelioma cancer is the growth of malignant cells in mesothelium. This mesothelium lining covers the pleural, peritoneal and pericardial cavities. Pleura is a membrane covering the lungs and it is the most common location where mesothelioma cancer occurs also known as pleural mesothelioma. Peritoneum, the protective covering that lines the abdominal cavity may also develop malignant tumors and cause peritoneal mesothelioma.

Mesothelioma is one of the rarest cancers in the world that is caused only by exposure to asbestos. Its exposure can be direct, by inhalation of asbestos or indirect exposure in which the asbestos particles are inhaled from the clothing, hair, equipment or other articles that were previously exposed to asbestos.

Causes of Mesothelioma
Asbestos is a naturally occurring fibrous mineral that is mined in different parts of the world due to its wide utility in various industries. However, it is a deadly carcinogen too and a mojor cause of mesothelioma and asbestosis.

Asbestos fibers are known to cause cancer of the mesothelium. Asbestos is the fibrous form of several minerals and hydrous silicates of magnesium found under ground. There are 3 types of asbestos, the blue one, the while one and the brown one. Of all these 3 types, the blue one also called amphibole, long and thin in structure is more carcinogenic than white or chrysolite asbestos or the brown one known as amosite.

However, in some cases the brown asbestos has also been found to cause mesothelioma. And it is for this reason that people exposed to asbestos even for a short period are vulnerable to the disease.

Pleural Mesothelioma
Asbestos fibers are very fine and easily make their way to the lungs where they settle down in the parenchyma of the lung and penetrate the pleura that later develops malignant mesothelial plaques.

Pleura, which anchors lungs to the chest cavity, is itself a double-layered membrane. The inner layer called visceral pleura surrounds the lungs, while the outer one, known as parietal pleura, forms the lining of the pleural or chest cavity. The two pleural layers are filled with a fluid that helps them to slide over each other as we breathe. As the disease progresses, the delicate pleural membranes thicken and press the lungs. A fluid secreted by the malignant cells, pleural effusion, may also collect between visceral and parietal pleurae that causes problem in breathing and other complications.

Peritoneum Mesothelioma
The asbestos fibers may also cause cancer in the peritoneum, known as peritoneal mesothelioma. This leads to thickening of the membranes surrounding abdominal organs and collection of a fluid, ascites in the abdominal cavity making it swell.

Though it is yet not clear how peritoneal mesothelioma develops, it is believed that from lungs, the asbestos fibers are transported to abdomen and its organs by the lymphatic system or they may be deposited in the gut through saliva contaminated by the asbestos fibers.

Pericardial Mesothelioma
This is the rarest type of mesothelioma cancer that comprises of only 5% of all the mesothelioma cases. Like other types of mesothelioma cancer, pericardial mesothelioma is also caused by the inhalation of asbestos dust and fibers. The lining of the chest cavity which protects the heart is known as pericardium. It is provided with a natural fluid or mucous that provide continuous lubrication to the heart so that it can work properly and perform its functions.

As the asbestos particles settle further into the lining of the chest or pericardial, the cancer spreads in the body. It destroys the heart tissues and muscles that is very hazardous to life and proves fatal for the patient.

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Mesothelioma is a deadly form of cancer that affects the serous membranes surrounding the major organs of the body i.e. the lungs, heart and the abdominal organs, causing these vital organs to inflate with excessive fluid. This fluid further causes the improper functioning of the organs. The only known cause of this cancerous tumor is asbestos exposure. In this disease, malignant cells are built up in the protective linings (serous membranes) of several internal organs known as mesothelium. Different organs in the abdomen cavity can get affected by mesothelioma because of the presence of the protective linings surrounding them. The most common types of mesothelioma include:

* Pleural Mesothelioma,
* Peritoneal Mesothelioma, and
* Pericardial Mesothelioma.

Pleural Mesothelioma:

Pleural Mesothelioma is a tumor in which the lining of the lungs, or lung pleura, gets affected by malignant cells. The pleura is a soft protective tissue that surrounds the lungs in the chest cavity. It helps the lungs in breathing (respiration) by producing a serous fluid that lubricates the pleural surfaces to avoid the teasing of the lungs against the chest wall. The malignant cells, once entered the pleura, begin to spread and affect the surrounding organs and tissues. This leads to further complications resulting pain and severe symptoms.

Mesothelioma affecting pleura is of two categories:

Diffused or Malignant (Cancerous):
It is the serious form of pleural mesothelioma that affects the pleural lining of the lungs and its surrounding organs.

Localized and Benign (Non-cancerous):
It is the non-cancerous form of mesothelioma, which does not affect all parts of the body except the pleura. However, it constricts the lung causing shortness of breath, and in some severe cases, pneumothorax (lung failure).

Peritoneal Mesothelioma:

Peritoneal Mesothelioma is a tumor of the peritoneum membrane or the abdomen lining, affecting many organs in the abdominal cavity including stomach. This form of mesothelioma cancer is less common than the pleural form but is more aggressive, resulting severe symptoms and short life expectancy. Like many other cancers, peritoneal mesothelioma can also be either malignant or benign.

Pericardial Mesothelioma:

Pericardial or Pericardium Mesothelioma is the rarest form of cancer, counting less than 10% of mesothelioma cases. In this form of cancer, fluid gets accumulated in the sac that encloses the heart. The main cause of this disease is the inhalation of asbestos fibers.

Due to the rarity of this disease, doctors and researchers have not clearly understood how the asbestos fibers enter the heart lining or pericardium. The only logical explanation so far about this form of cancer is the possibility of the asbestos fibers, converted into tiny pieces, transported from the lung into the heart by means of blood circulation. Once the asbestos fibers enter the heart, they expand the tissues in the chest cavity and the pericardium with excessive liquid, disrupting the working of the heart and causing chest pains with breathing disorders.

Each year, approximately 2,000 new cases of mesothelioma are diagnosed. At some point of their lives, the patients of mesothelioma have been exposed to asbestos that later cause the hideous cancer of mesothelioma. If you, at some point of your life, have worked in an asbestos-rich environment or used any asbestos materials, you should contact a mesothelioma doctor for correct diagnosis and best treatment options available.

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Mesothelioma treatments have thus far been unable to limit the spread of the deadly cancer. Treatments for mesothelioma are divided into two categories; traditional mesothelioma treatments and new mesothelioma treatments.
Traditional mesothelioma treatments are the same as those used to treat most other cancers, and include:
Surgery
Chemotherapy
Radiation therapy (radiotherapy)

Traditional mesothelioma treatments are often used in conjunction with one another in effort to provide the most thorough and effective method of treatment. For example, trimodality therapy combines all three traditional methods of treatment, where chemotherapy is administered first with the aim of slowing the growth of malignant mesothelioma. Chemotherapy treatments are followed by surgery designed to physically remove a mesothelioma tumor mass (extrapleural pneumonectomy is often performed as part of trimodality therapy). Postoperative radiation therapy is used for the final step, to target any lingering mesothelioma cells. Although trimodality therapy has been unable to eradicate malignant mesothelioma, it has proven to be effective in significantly prolonging patients’ survival time by as much as five years (the average post-diagnosis survival time is one to two years).
New mesothelioma treatments have been researched and developed with the hope of succeeding where traditional methods have not. Mesothelioma researchers are optimistic that new mesothelioma treatment modalities will eventually prove to be successful, though they have yet to yield results that are any better than traditional methods.

New treatments for mesothelioma include:
Development of new chemotherapy agents
Intensity modulated radiation therapy (IMRT)
Photodynamic therapy (PDT)
Immunotherapy
Gene therapy
The progression of mesothelioma, as with other cancerous diseases, is typically broken into stages, with the treatment options based on the stage of the disease. The commonly used staging for mesothelioma is the Brigham staging system and it is described as follows.
Stages of Mesothelioma
Stage 1 occurs when the tumor lies completely within the capsule of the pleura, without swollen lymph nodes (adenopathy).
Stage 2 has the characteristics of Stage 1, where the tumor has spread and there is presence of adenopathy. But in Stage 2 the boundaries of the tumor allow for a resection (removal of the tumor) without cutting into other organs.
Stage 3 includes extension of the disease into the chest wall or into the heart, through the diaphragm or peritoneum, or outside the pleura to involve the lymph nodes.
Stage 4 occurs when the cancer has formed in distant organs through metastases.
Treatment options for the management of malignant mesothelioma include:
chemotherapy
surgery
radiation
multimodality treatment
However, none of the treatment strategies have been shown to be particularly effective against the disease.

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Malignant mesothelioma detection, like other cancers, can be accomplished with imaging equipment, such as x-ray machines. But once detected, mesothelioma diagnosis is difficult for a number of reasons. First, there is a very extended time period between the exposure to asbestos and the onset of the disease, sometimes as long as 50 to 60 years. Patients would often not think to tell their doctors about working in an asbestos-related job many years earlier.

Second, the typical symptoms of mesothelioma, shortness of breath and coughing, are also symptoms of many other types of lung problems, both cancerous and non-cancerous. Thus, just because a person has these symptoms, it does not in any way provide a mesothelioma diagnosis.
Third, many types of tumors can exist in the serous cavities that are not mesothelioma. These other types of tumors can be non cancerous, or benign, that originate in the tissues of the serous membranes, other than the mesothelium. Or they can be tumors that have migrated from other organs with cancerous growths due to metastases.
Mesothelioma and Imaging Technologies
X-rays and other types of imaging technologies can be used to detect tumors or effusion (build up of fluid) in the body, including mesothelioma detection. A growth in the chest cavity will show up in an X-ray or MRI analysis. But these devices cannot directly determine the type of cancer or provide a mesothelioma diagnosis. They cannot determine whether the tumor is mesothelioma or originates from some other source.

Positron emission tomography (PET) is a type of diagnostic imaging scan that is used for malignant mesothelioma detection. PET scans use the emission of positrons (tiny particles that are emitted from radioactive substances) for the purpose of radiation detection.
Some medical professionals are of the impression that PET scans are the most effective method through which to definitively verify a case of mesothelioma. While they believe that standard imaging techniques like x-rays and MRIs should continue to play a role in diagnosing the disease, it is felt that positron emission tomography is becoming an increasingly valuable tool in the staging and typing of the latent asbestos cancer.
Diagnostic Surgery – Biopsy
To provide a mesothelioma diagnosis, a biopsy is needed. This biopsy then undergoes what is called diagnostic histopathology. Histopathology is a technique where the cells from the tumor are viewed under a high-powered microscope, or electron microscopy. Electron microscopy is considered the gold standard for evaluating tumor material from a biopsy. It is a highly advanced microscope that allows viewing of the tiniest elements of cell tissue.
For mesothelioma diagnosis, a pathologist (a doctor who specializes in disease detection) places the tumor cells in the electron microscope and then views the structure of the individual cells. The mesothelioma cells have a specific shape and pattern, and this allows them to be identified by a very keen pathologist. But mesothelioma cells also look similar to other types of cancer cells, such as adenocarcinoma cells, and this can make the pathologist’s job very difficult. Even with the electron microscope, the different types of mesothelioma cells can be hard to recognize. The three types of cells are epithelioid mesothelioma cancer cells, which are tubular in shape, sarcomatoid mesothelioma cancer cells, which are oval and irregularly shaped, and biphasic mesothelioma cancer cells, which are a combination of shapes. These cells can be confused with other types of cancer cells.
New Methods For Mesothelioma Detection
Due to this diagnostic confusion, much research is underway to find new methods for diagnosis. One method is to evaluate the types of compounds generated by the mesothelioma cancer cells. This is called histochemistry. Histochemical reactions have long been used to distinguish between mesothelial and other types of tumor cells. For example, mesothelial cells are known to produce specific types of carbohydrate compounds. Unfortunately, other types of cells in the body also produce these compounds.
Immunochemistry is also being used to detect mesothelioma. This area of study evaluates the presence of antibodies in the body. Certain types of antibodies are known to be associated with certain types of cancer. But mesothelial cells have no specific types of antibodies that can provide a “positive” marker. Consequently, immunochemistry allows the doctor to “eliminate” the other cancers, but does not indicate the presence of mesothelioma. These techniques offer insight into the disease and may help eliminate other diseases, but none can directly detect mesothelioma.
New Blood Tests for Mesothelioma Detection
SMR Protein: Recently, because of the difficulty in diagnosing malignant mesothelioma, research has concentrated on finding new ways to detect the presence of the disease. Researchers in Australia have found that a certain protein, called SMR or Soluble Mesothelin Related protein, is elevated in patients with mesothelioma. These researchers have suggested that a test for the presence of SMR in the blood could represent a useful marker for the diagnosis and disease progression. They feel that such a diagnosis tool could lead to earlier detection, and thus more effective treatment.
One of the most striking findings of their research was that several asbestos-exposed persons who tested positive for SMR were diagnosed with mesothelioma within three years. They suggested that evaluation of SMR may help to identify persons at risk for this deadly disease. Also, they found that SMR levels increase as mesothelioma progresses, suggesting that SMR evaluation could be used to track the progression of the disease and the effectiveness of treatment
Osteopontin Glycoprotein: In an effort to produce the first early-detection test to screen for malignant mesothelioma, researchers at Wayne State University have been studying the possible link between mesothelioma development and levels of a glycoprotein called osteopontin. Early clinical study findings of 190 patients have demonstrated a link between high levels of osteopontin and the development of malignant pleural mesothelioma.
Although the results are being viewed as preliminary, there is a great deal of excitement surrounding the potential of a blood test capable of screening for mesothelioma in its earliest stages. While there is no known cure for malignant mesothelioma, research is ongoing and certain successes have already been realized in terms of extending survival time beyond the one to two year post-diagnosis average. It is hoped that if mesothelioma specialists have more time through which to conduct treatment on a lesser developed form of the asbestos cancer, the greater a patient’s chance at potential survival.
Despite the fact that the preliminary results of the osteopontin blood test clinical trial have been met with some controversy, the National Cancer Institute (NCI) continues to sponsor additional study.
Tell Your Doctor About Asbestos Exposure
If you or a loved one has been exposed to asbestos, even if it was in the distant past, it is very important that you inform your doctor. One reason why mesothelioma is such a deadly disease is that it is detected late in the disease process. If your doctor knows of the exposure, he or she may be more aware of your symptoms or other health issues that could be used for early detection.

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Malignant mesothelioma is a rare form of cancer that affects the mesothelial cells of the serous membranes in the body. The most common form of mesothelioma, affecting the lining of the lung, is pleural mesothelioma. Two to three thousand new cases of malignant mesothelioma are diagnosed each year.

The mission of All About Malignant Mesothelioma is to provide a one-stop resource for comprehensive, up-to-date mesothelioma information. We cover the full scope of malignant mesothelioma issues including background, history, risk factors, diagnosis, and treatment. Please recommend the site to someone who may benefit from mesothelioma information.
Introduction to Malignant Mesothelioma
Malignant mesothelioma affects the lining or membranes of certain large cavities in the body. These cavities, called the serous cavities, house certain major organs in the body including the heart, lungs, abdomen and others. The membranes that surround these cavities are called the serous membranes. They serve to protect these major organs from the friction and abrasion that occur as the organs move against each other during typical daily functioning, such as breathing and heart beating. The serous membranes derive from specialized cells called mesothelial cells. These cells form to create the mesothelium, which is the major tissue layer of the serous membranes. Cancer that occurs in the mesothelium tissue is called mesothelioma.

Malignant mesothelioma takes on three forms:
Peritoneal mesothelioma, in the peritoneum or membrane surrounding the abdomen. A rare form of peritoneal mesothelioma can also affect the male testicles, because the lining around the scrotum is an extension of the peritoneum.
Pericardial mesothelioma, in the perdicardium or lining surrounding the heart.
Pleural mesothelioma, which is the most common form of malignant mesothelioma and affects the lining of the lung cavity.
All mesotheliomas are now considered to be malignant, or cancerous. They start as a localized tumor and spread rapidly to include most of the surrounding tissues and organs. Originally, fibrous cists and other non-cancerous growths that appeared in the serous membranes were thought to be mesotheliomas and were termed “benign fibrous mesothelioma” and “multicystic mesothelioma.” These conditions are now known not to originate in the mesothelial cells, but other cells within the serous membranes. These conditions are typically localized, non-cancerous and do not spread rapidly.
Etiology of Malignant Mesothelioma
Most cases of malignant mesothelioma are associated with a previous exposure to fibrous minerals, of which asbestos is the most important. There is now indisputable evidence of the role of these fibers in the development of this disease. This has been demonstrated in animal experiments and many other experiments. Not everyone who is exposed to asbestos fibers has developed malignant mesothelioma, suggesting that other factors may also be involved.
Although malignant mesothelioma is rare, it is a serious, deadly disease. It is often in the advanced stages when it is detected, so the outlook for the patients is not as good as it is for the cancers that are detected earlier. The average survival time after detection is 1 to 2 years. This survival time also depends on the type of mesothelioma.

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