Archive for the tag 'clinical tests'

The hunt for a cure for mesothelioma - experimental treatments and clinical trials

The research and studies continue to find a remedy for mesothelioma. It is there that we are trying to update and find new treatments, creative plans, tools and solutions for the management, processing and regulation of the disease and the quality of life for patients with this disease. He takes the patient about their breaths very valuable life.

Evaluation of the efficacy of new treatments, therapies and medicines or medical interventions is currently for most doctors and specialists in this field, a passionate and urgent, and the continuation and the commitment seriously, undisputed. The race has started for a cure to find this rare type of cancer.

The new technology and the procedures that are the subject of trials in experimental and clinical tests and progress, but only small steps at a time. We reserve the secret decommissioning and murderers secrets of the killer cancer.

Here are some examples of some of the progress and the ongoing studies on time:

Combined with Chemotherapy
More than one treatment, both the approaches proved to be satisfactory. The mixed results, sometimes just deepens the complexity of these diseases, which makes it clear that he is no longer here, that meets the eye. The cocktails and mixtures of drugs to be tested in clinical trials on real patients and the results published in medical journals. Most of the patients well respond to treatment and believe that they play their part to the progress of science and the treatment itself, but also many others.

Intra-chemotherapy cavitaires
Invasive internal and aggressive treatment by the application in the treatment of chemotherapy drugs or elements directly into the cavities (like a concentrated, and much higher dose, localized) This is and was a success, with a minimum d ’side effects and the results seem promising. It significantly reduces the damage and the spread something. He is the carrier of hope for other experiments and clinical trials in the coming years.

Brachytherapy or radiation therapy (radioactive) are treatments that directly into the abdomen or chest.

Multimodality combination of therapies and treatments, where the methods used are surgery, chemotherapy and radiation therapy of a patient in order to optimise the success of the disease and to survive, have a quality of life in their last days, and dying with dignity and pain associated with the management of the progressive nature of the disease.

Gene
It is a revolutionary form of treatment and experimental mesothelioma. It consists of a genetically produced viruses and to the impact of the disease, to repair the damage and progression. It attacks the cancer cells and tumors, regions, stains, all in an attempt to intervene and to heal.

Immunotherapy
Patients a fight against change and improve their quality of life, these approaches usually focuses on the immune system, by an impetus to the fight against the disease. It enhances the natural ability to want to restore the balance and to restore itself to heal.

Photodynamic therapy
Photosensibles are medicines for the treatment of tumors or assigned to the zone.

There are many other examples, and always the hope that the cure lies in the magnitude of the next corner! The prosecution and the efforts in this area.

A study shows the improvement pleural mesothelioma patients who cisplatin more raltitrexed

Mesothelioma pleural mesothelioma patients treated with cisplatin and raltitrexed may survive longer than patients who cisplatin alone, according to a study in Europe and Canada (J Clin Oncol. 2005 Oct 1, 23 (28): 6881 - 9). Raltitrexed (Tomudex), with a capacity of the cancer cells to multiply and make the deoxyribonucleic acid or DNA. The cisplatin is a medicine from conventional chemotherapy.

Two one hundred fifty patients with pleural mesothelioma participated in a clinical trial to determine the safety and effectiveness of raltitrexed. Hundred Twenty-four patients received cisplatin, and the rest has more raltitrexed cisplatin. Most were men with an average age of 58 who do not have the additional treatment with chemotherapy.

Raltitrexed The study was a phase III clinical tests, as proposed by the European Organization for Research and Treatment of Cancer. Phase III comparison a new therapy against cancer with a standard treatment, and requires a large number of participants. It follows on from a clinical study of the phase II, which deals with the safety of a new treatment and the way the administration and a clinical phase I trial of the efficacy tests drugs on a small number of patients.

Increase the survival rate among patients with raltitrexed The researchers have investigated the survival, the progress of pleural mesothelioma, security, the tumor response rate, the patients and the quality of life. They have discovered, what follows:

“About six percent of patients with pleural mesothelioma in the cisplatin group raltitrexed survived at least one year, compared to 40% of the cisplatin group.

“The average survival was of 11.4 months for patients in the cisplatin / raltitrexed group, but only 8.8 months for patients in the group with cisplatin.

“Twenty-four percent of patients receiving cisplatin / raltitrexed had a positive response against the pleural mesothelioma, compared to 14% of patients receiving cisplatin.

“The quality of life in general was roughly in the group of cisplatin compared to the cisplatin group raltitrexed.

A small number of patients, both in the cisplatin cisplatin and raltitrexed groups developed lower white blood cell count (neutropenia). Other side effects included fatigue, nausea and vomiting, often in the group of combination drugs.

Raltitrexed is relative to the Pleural Mesothelioma Drug raltitrexed Alimta ® is in the class of so-called antifolates chemotherapy. It blocks the production of thymidylate synthase, back, which decreases its ability mesothelioma cell, the DNA, the genetic material of the base, in the reproduction of cells. It is in Europe for the treatment of advanced colorectal cancer.

Raltitrexed is closely connected with pemetrexed (Alimta ®), another antifolate. Currently pemetrexed / cisplatin is the only combination therapy of chemotherapy, that the U.S. Food and Drug Administration has in the treatment of pleural mesothelioma.