Mesothelioma Cancer

by Mr.sc. Adam Vrancic

Medical thoracoscopy in the diagnosis of unexplained pleural effusion.

Respirology 1998 Jun;3(2):77-80

Wilsher ML, Veale AG

Respiratory Services, Green Lane Hospital, Auckland, New Zealand.

Approximately 20% of pleural effusions remain without an established aetiology after evaluation. Thoracoscopy has a very high sensitivity for the diagnosis of both benign and malignant diseases and greatly increases the diagnostic yield for pleural effusion. We sought to evaluate the diagnostic yield and safety of medical thoracoscopy at this institution.

The records of all patients undergoing medical thoracoscopy for the evaluation of undiagnosed pleural effusion between 1990 and 1996 were reviewed. The procedure was performed under local anaesthesia with sedation using a Stortz rigid thoracoscope. Fifty-eight patients had thoracoscopy, most having had two (range: 1-6) non-diagnostic pleural aspirations and biopsies of the pleura. Nineteen patients were found to have mesothelioma and nine metastatic malignancy. Three patients were considered likely to have tuberculous pleural disease, six had asbestos related benign pleural fibrosis and three post-cardiotomy syndrome.

There was one chylous effusion of uncertain aetiology, one posttraumatic and two other benign effusions, both of which resolved without clear aetiology. On seven occasions the pleural space could not be adequately accessed, but none of these patients had prior computerized tomography (CT) or ultrasound of the pleural space. There were five false negative diagnoses of malignancy, but no false positives.

The diagnostic sensitivity for pleural malignancy was 85% and specificity 100%. There were no major complications, but four patients had late tumour seeding at the thoracoscopy site. Medical thoracoscopy is a safe procedure with a high diagnostic yield. Pre-operative evaluation of the pleural collection using ultrasound or CT increases the likelihood of successful access to the pleural space and may increase diagnostic yield.

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Mesothelioma cancer is a disease that results from exposure to asbestos related substances. Asbestos usually consists of fibres that can enter the body through the mouth, or the skin, and, subsequently, enter the lungs, or blood stream.

Mesothelioma cancer has become more widely documented in the last 5-10 years, due to the fact that symptoms of asbestos cancer can take between 20 to 40 years to manifest. Mesothelioma cancer is hard to diagnose, as the symptoms do not tend to manifest themselves until the later stages of the disease. Symptoms of mesothelioma lung cancer include shortness of breath, chest pain, fever and other secondary illnesses such as pneumonia.

Asbestos cancer most often develops in men between the ages of 50 to 70 years who were exposed to high levels of asbestos in the workplace. Asbestos was mainly used in manufacturing industries such as automotive and ship building as well as in the construction industry. The use of asbestos was only recently banned in the 1990’s.

Mesthelioma lung cancer has been found to be the most common form of mesothelioma cancer and it develops in the lining of the lung (pleural). Mesothelioma cancer can also develop in the abdominal area (peritoneal) and around the heart (pericardial). There is a greater chance of malignancy in abdominal asbestos cancer. For a more detailed explanation of mesothelioma cancer, visit http://www.lung-canceradvice.com

Mesothelioma lung cancer can be detected through a CT scan which enables it to be sometimes diagnosed earlier than the other two types of mesothelioma cancer. The type of mesothelioma cancer treatment will depend on the stage at which the cancer was diagnosed, the age of the patient as well as personal preferences. The disease can be divided into four separate stages. The stage in the disease process that is reached will determine the method of mesothelioma cancer treatment. At the first stage when the tumour is confined to the lining of the lungs, surgeons may try to remove the entire tumour surgically. Once the tumour has invaded the surrounding body tissues in the later stages, it is not curable. Read more >>>>

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Mesothelioma is a form of cancer. It caused by previous exposure to asbestos. An exposure of as little as one or two months can result in mesothelioma 30 or 40 years later. Simian virus 40 (SV40) may act as a cofactor in the development of mesothelioma. Malignant mesothelioma is the most serious of all asbestos-related diseases. The two major types of malignant mesothelioma are pleural mesothelioma, which concerns the mesothelium membrane that surrounds the lungs, and peritoneal mesothelioma which concerns the mesothelium layer that covers the organs in the abdominal cavity. The people most at risk from being carriers of this cancer are those have worked with asbestos over the past thirty to fifty years. Because of this, the disease is most common in men between the ages of sixty and seventy as this is the group that commonly worked with asbestos during those years. Because of the lack of protection and regulations in those days, these workers were constantly exposed to the dust and fibres from the asbestos, which caused the cells of the mesothelium to become abnormal. Many building materials used in both public and domestic premises prior to the banning of asbestos may contain asbestos. Those performing renovation works or diy activities may expose themselves to asbestos dust.

Mesothelium helps protect the organs by producing a special lubricating fluid that allows organs to move around. Mesothelioma is an extremely malignant and incurable cancer that infects the membrane that surrounds most of the internal organs. Symptoms of mesothelioma may not appear until 20 to 50 years after exposure to asbestos. Shortness of breath, cough, and pain in the chest due to an accumulation of fluid in the pleural space are often symptoms of pleural mesothelioma. Affecting the mesothelial cells that make up the mesothelium – the outer lining that protects the body’s major organs such as the heart, stomach and lungs. Pleural mesothelioma represents 75% of mesothelioma cases - but it is far from the only type of this deadly cancer. Peritoneal mesothelioma affects the lining around the stomach and intestines, and is just as dangerous and deadly. Treatment of MM using conventional therapies has not proved successful and patients have a median survival time of 6 - 12 months after presentation. The clinical behaviour of the malignancy is affected by several factors including the continuous mesothelial surface of the pleural cavity

Mesothelioma Cancer Treatment and Prevention Tips

1. Health-care workers who specialize in part control are employing state-of-the art techniques to successfully fight pain.

2. During the initial stages of mesothelioma, pain can be relieved with over-the-counter analgesics, such as aspirin, Tylenol or ibuprofen (Advil, Motrin).

3. Drug therapy is the primary method for treating mesothelioma pain.

4. Non-Opoids are pain-relieving medicines such as acetaminophen (Tylenol) and NSAIDs, such as ibuprofin, which can be purchases over-the-counter and taken orally.

5. Opoids are the strongest medicines available to treat pain. Opoids, such as codeine, morphine, oxcodone, fentany, and hydromorphone, are very effective in relieving mesothelioma pain.

6. Adjuvant analgesics are medicines intended for purposes other than pain relief. A number of these are used to alleviate pain associated with mesothelioma, such as antidepressants, anticonvulsants, and steroids.

7. Emotional Support to Help Relieve Pain.As with all aspects of mesothelioma, emotional support from family or professional counseling can play a key role in pain management

8. For patients with localized disease, and who can tolerate a radical surgery, radiation is often given post-operatively as a consolidative treatment.

9. Chrysotile has been used more frequently, hence many mesotheliomas are caused by chrysotile.

10. Removal is taking place in schools and other public buildings throughout the U.S. The hope is that these measures will greatly reduce the occurrence of this cancer.
Author: Juliet Cohen

—
Juliet Cohen writes articles for http://www.healthatoz.info/ and http://www.health-disease.org/

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Mesothelioma cancer is a disease that results from exposure to asbestos related substances. Asbestos usually consists of fibres that can enter the body through the mouth, or the skin, and, subsequently, enter the lungs, or blood stream.

Mesothelioma cancer has become more widely documented in the last 5-10 years, due to the fact that symptoms of asbestos cancer can take between 20 to 40 years to manifest. Mesothelioma cancer is hard to diagnose, as the symptoms do not tend to manifest themselves until the later stages of the disease. Symptoms of mesothelioma lung cancer include shortness of breath, chest pain, fever and other secondary illnesses such as pneumonia.

Asbestos cancer most often develops in men between the ages of 50 to 70 years who were exposed to high levels of asbestos in the workplace. Asbestos was mainly used in manufacturing industries such as automotive and ship building as well as in the construction industry. The use of asbestos was only recently banned in the 1990’s.

Mesthelioma lung cancer has been found to be the most common form of mesothelioma cancer and it develops in the lining of the lung (pleural). Mesothelioma cancer can also develop in the abdominal area (peritoneal) and around the heart (pericardial). There is a greater chance of malignancy in abdominal asbestos cancer. For a more detailed explanation of mesothelioma cancer, visit http://www.lung-canceradvice.com

Mesothelioma lung cancer can be detected through a CT scan which enables it to be sometimes diagnosed earlier than the other two types of mesothelioma cancer. The type of mesothelioma cancer treatment will depend on the stage at which the cancer was diagnosed, the age of the patient as well as personal preferences. The disease can be divided into four separate stages. The stage in the disease process that is reached will determine the method of mesothelioma cancer treatment. At the first stage when the tumour is confined to the lining of the lungs, surgeons may try to remove the entire tumour surgically. Once the tumour has invaded the surrounding body tissues in the later stages, it is not curable.

Conventionally, the more advanced stages of mesothelioma cancer are treated with either radiation therapy or chemotherapy. Radiation therapy utilizes high-energy x-rays to destroy cancerous cells and shrink tumours Chemotherapy, on the other hand, uses drugs to destroy cancer cells. The aim of these mesothelioma cancer treatments is to prolong the patient’s life as the disease cannot be cured in the more advanced stages.

In addition to these conventional mesothelioma cancer treatments, there are also various experimental treatments currently under investigation which offer new hope.

Immunotherapy: This form of biological therapy for mesothelioma cancer treatment uses the patient’s own immune system to attack the cancerous cells. Clinical studies have shown that the immune system is able to distinguish healthy cells from cancer cells, and can therefore be used to destroy those cancerous cells.

Gene Therapy: This form of mesothelioma cancer treatment is very much still in the developmental stages. The process involves injecting a specific gene straight into the tumour. This gene renders the cancer cells sensitive to the antiviral drug glanciclovir which under normal circumstances is not effective against these cells. The glanciclovir is then able to destroy all the cancer cells without harming the healthy tissue cells.

Drug Therapy: The drug Alimta is the only chemotherapy drug to be approved by the Food and Drug Administration (FDA)for the treatment of patients with malignant mesothelioma lung cancer . This new and exciting drug has been demonstrated in clinical trials to reduce symptoms and increase the life expectancy of patients.

Photodynamic Therapy: Photodynamic therapy involves the use of light to destroy cancer cells. The patient first is first administered a photosensitizing drug that only collects in cancerous cells. Fibre-optic cables are then inserted in the body in order to focus light of a certain frequency on the tumour. The light stimulates the photosensitizing drug to produce toxic oxygen molecules that destroy the cancerous cells.

These experimental mesothelioma cancer treatments, although still in the developmental stages, offer cancer victims the prospect of a better and longer life. With the likelihood of an increase in the number of people diagnosed with asbestos cancer, further research into other forms of mesothelioma cancer treatment is vital.

Note to Publishers: You may freely republish this article as is, without editing or modification, and all links must be kept live. The author, Gregory De Villiers, writes on a variety of health and wellness topics. For more information on mesothelioma cancer as well as asbestos litigation, visit http://www.lung-canceradvice.com

Source: http://www.articlealley.com/article_121761_17.html

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Asbestos lung mesothelioma is a rare cancer, which can be in the cells specific lubrication, a bag around the lungs. This can be between 10 and 60 years to develop, but in most cases, the mean of 30 to 50 years, that the symptoms of the victims of lead time for a doctor.

Despite its name, it is not really lung cancer, that the lungs is not the first site of malignancy. Instead, it is the support of the lung tissue, the cancer cells. The tissue around the lungs or almost 75% of the cases diagnosed, but also the tissues of other organs can also use the Web sites of cancer elementary school opening.

Currently, there are between two and three thousand new cases diagnosed in the United States each year (US National Cancer Institute, 2002).

This disease accounts for about 75% of the cancers by asbestos exposure.

Asbestos is a mineral deposits, the quality of heat insulation. There was widespread in the whole world during the last century in the areas of military, construction and consumer goods until it banned carcinogenic effect. People can in the community, at work, at school, at home or from the clothing others who have been exposed. It is likely that most people were at a certain time in their lives.

The mineral composition creates a quality that is very fragile. He breaks into pieces, then crumbles easily. This allows the microscopic particles in the air, where they go unnoticed for long periods of time.

People can inhale these particles minerals without knowing it. The movement of the particles in the lungs, which Alveolarluft bags, and found in the lungs of support. It is impossible to remove them if the mineral particles to remain there. They can cause cancer slowly stupid.

This condition is currently considered incurable. Normally there are very few symptoms until the next steps if the cancer metastases. After the diagnosis the average survival period of between one and two years.

Early detection offers a great advantage. It is always recommended that people who suspect that they are the burden of the environment to find a doctor for a specialized training to monitor their state of health, as soon as possible.

The treatment is chemotherapy, radiation therapy and surgery.

After decades of experience, medical research is focused now on to slow or prevent the development of cancer. By learning all biochemical, in the introduction, development and the spread of the cancer, the researchers hope that they will find ways to change, as the cancer grows.

Since the asbestos lung mesothelioma can take decades to develop the deadly malignant, we can expect more, that the early interventions provide people with a normal life. Scientists explore new therapies including natural substances that lead to a good result in a laboratory in cancer prevention.

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